АНДЕРСОН Дэниел Г. (US),ГУ Чжэнь (US),ЭЙМЕТТИ Алекс Артур (US),ЛАНГЕР Роберт С. (US)
申请号：
RU2015151135
公开号：
RU2015151135A
申请日:
2014.04.29
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
A system for &ldquosmart&rdquo delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through an injectable nano-network consisting of oppositely-charged dextran nanoparticles encapsulating insulin and glucose-specific enzymes forming a gel-like 3D scaffold. As demonstrated by the examples, the system effectively dissociates to release insulin in a hyperglycemic condition, where the catalytic conversion of glucose into gluconic acid and the subsequent degradation of polymeric matrix are facilitated. This formulation design provides a delivery strategy for both self-regulated and long-term diabetes management.
