Pyridazinone derivatives as parp inhibitors

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专利权人:

ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.

发明人:

DANILA BRANCA,GABRIELLA DESSOLE,FEDERICA FERRIGNO,PHILIP JONES,OLAF KINZEL,SAMUELE LILLINI,ESTER MURAGLIA,GIOVANNA PESCATORE,CARSTEN SCHULTZ-FADEMRECHT

申请号：

BRPI0820236

公开号：

BRPI0820236A2

申请日:

2008.11.14

申请国别(地区):

BR

年份:

2015

代理人:

摘要：

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.

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