Bernhard Hubert GEIERSTANGER,Jan GRUNEWALD,Yunho JIN,Weijia OU,Tetsuo UNO,Yongqin WAN,Xing WANG
申请号：
US16439204
公开号：
US20190382441A1
申请日:
2019.06.12
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed herein are novel cytotoxic peptides of formula (I) as described herein:and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody； where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
