The present invention relates to a method and device for treating patients with a Protein Misfolding Disease by chronically administering an effective dose of a thrombolytic reagent and/or a thrombolytic reagent regulator over an intermittent period of time. The thrombolytic reagents degrade the misfolded proteins that accumulate and that can become toxic in such patients. The thrombolytic reagent regulators increase the catalytic efficiency of the thrombolytic reagents to reduce the amount of thrombolytic reagents necessary for an effective dose. The administration is administered transdermally via a transdermal patch that is equipped with an ultrasound transducer for enhancing the penetration of the thrombolytic reagent and thrombolytic reagent regulator into the bloodstream of a patient by increasing the permeability of the patients skin.
