Quinoxaline derivatives as inhibitors of Janus kinase tyrosine kinase activity

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专利权人:

ノバルティス アーゲー

发明人:

マルク・ゲルスパッハー,パスカル・フュレ,エリック・ヴァングレーヴランジュ,キャロル・ピソ・ソルドマン,クリストフ・ガウル,フィリップ・ホルツァー

申请号：

JP2010510815

公开号：

JP5574957B2

申请日:

2008.06.06

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention relates to quinoxaline compound of the formula (I): wherein R1 is carbocyclyl or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R7； R2 is carbocyclyl or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R8； R3, R4, R5 and R6 are each independently hydrogen or R9； and R7, R8 and R9 are each independently selected from organic and inorganic substituents, their use in therapy of diseases, in particular diseases mediated by the tyrosine kinase activity of Janus kinases, including JAK-2 and JAK-3 kinases.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/