A method for protecting a pressure transducer from fluid pressure damage using a pressure isolation mechanism is disclosed. The method includes associating the pressure transducer with an isolation port of the pressure isolation mechanism, placing a pressurizing device for delivering fluid under pressure in fluid connection with an inlet port of the pressure isolation mechanism, and actuating the pressurizing device to cause fluid flow in the inlet port such that a free floating, fluid flow responsive valve member positioned in an internal cavity of the pressure isolation mechanism engages a seal seat therein to attain a closed position, preventing fluid flow between the inlet port and the isolation port and thus prevent overpressure in the isolation port. Hemodynamic pressure signals read with the pressure transducer may be transmitted at least in part through a body of the valve member, or a portion thereof, when in the closed position.
