DE BONT, Nicolaes Hubertus Maria,DAVISON, Noel L.,WIERMANS, Mandy Maria Jozefina
申请号：
EPEP2020/055417
公开号：
WO2020/178228A1
申请日:
2020.03.02
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Disclosed herein is a method of making a composite fabric for use in or as a medical implant component, the method comprising steps of providing a textile comprising at least one strand having titer of 2-250 dtex and comprising fibers made from a biocompatible and biostable synthetic polymer； determining locations on the textile where a cut is to be made for an intended use of the textile； optionally pretreating the textile at least at the determined locations on at least one side of the textile with a high-energy source to activate the surface； solution coating the textile at least at a determined location with a coating composition comprising a biocompatible and biostable polyurethane elastomer and a solvent for the polyurethane； removing the solvent from the coated textile； and laser cutting the coated textile as obtained at least a one coated location with an ultra-short pulse laser； to result in a composite biotextile wherein polyurethane is present in an amount of 2.5-90 mass% based on composite biotextile and polyurethane is present at least at a laser-cut edge. Such composite biotextile as made shows an advantageous combination of good biocompatibility, especially hemocompatibility, high strength and pliability, and has well-defined regular edges that have high suture retention strength. Further embodiments concern the use of such composite biotextile in or as medical implant component for an implantable medical device； such as in orthopedic applications and cardiovascular implants. Other embodiments include such medical devices or implants comprising said composite biotextile or medical implant component.La présente invention concerne un procédé de fabrication d'un textile composite pour l'utilisation dans ou comme élément d'implant médical, le procédé comprenant les étapes consistant à fournir un textile comprenant au moins un brin ayant un titre de 2 à 250 dtex et comprenant des fibres fabriquées à partir d'un polymère synthétique biocompatible et biostab
