結合ＣＤ２８之單價組合物及其使用方法农业专利-农业专业知识服务系统

发明人:: MCKINNON, MURRAY,麦可奇纳恩　莫瑞,麥可奇納恩　莫瑞,NADLER, STEVEN G.,耐德勒　史蒂芬Ｇ,SUCHARD, SUZANNE J.,苏查德　苏珊Ｊ,蘇查德　蘇珊Ｊ,CLASSON, BRENDAN,克雷森　布兰登,克雷森　布蘭登,HOLMES, STEVE,荷姆斯　史蒂夫,IGNATOVICH, OLGA,英格纳托维奇　欧加,英格納,麦可奇纳恩莫瑞,麥可奇納恩莫瑞,耐德勒史蒂芬G,苏查德苏珊J,蘇查德蘇珊J,克雷森布兰登,克雷森布蘭登,荷姆斯史蒂夫,英格纳托维奇欧加

摘要：: Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.本發明揭示單價結合CD28之域抗體。結合CD28之單價域抗體可抑制CD28活性。在一態樣中，域抗體由單一免疫球蛋白可變域組成或包含單一免疫球蛋白可變域，特異性結合CD28且拮抗CD28活性，在一態樣中，實質上不促進(agonizing)CD28活性。在另一態樣中，該域抗體為人類域抗體。本發明另外涵蓋拮抗個體中CD80及/或CD86與CD28相互作用的方法，及治療涉及CD80及/或CD86與CD28之相互作用的疾病或病症的方法，該等方法涉及向該個體投與域抗體。