Murray McKinnon,Steven G. Nadler,Suzanne J. Suchard,Brendan Classon,Steve Holmes,Olga Ignatovich,Christopher Plummer,Steve Grant
申请号：
US15870121
公开号：
US20180142023A1
申请日:
2018.01.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.
