The present invention refers to inhibitors of microRNAs, particularly ofmicroRNAsmiR-212 for use in medicine, particularly in the diagnosis, treatment orprevention of cardiacdisorders, e.g. cardiac hypertrophy-associated or autophagic disorders, andfurtherrefers to isolated nucleic acid molecules, particularly microRNAs miR-212 andrelatedsequences, for use in medicine, particularly human medicine, more particularlyin thediagnosis, treatment or prevention of disorders involving cardiac atrophyand/ordysfunctional autophagy, e.g. cardiac cachexia.