PROBLEM TO BE SOLVED: To provide a chronic inflammatory disease therapeutic agent which is also effective for type II diabetes.SOLUTION: The chronic inflammatory disease therapeutic agent includes a compound expressed by formula (I) [wherein, either Ar1 or Ar2 denotes an aromatic group at least having a nitro group as a substituent R1 denotes H atom or an alkyl group R2 denotes H, an alkyl group or an aromatic group or -CONH- and is bonded to the 2-position of the Ar2 and R1 and R2 jointly may denote a group shown by following formula:-C(R3)(R4)-C(R5)(R6)-] or its salt (excluding a compound wherein Ar1 denotes a 2-nitrophenyl group Ar2 denotes a 3-cyclopentyloxy-4-methoxyphenyl group R1 denotes H and R2 denotes H and a compound wherein Ar1 is a 2, 4-dinitrophenyl group Ar2 denotes a 3, 4, 5-trimethoxyphenyl group R1 denotes H and Rr2 denotes a 6-methoxy-2-(1-methyl-1H-pyrazole-4-yl)benzo[b]furan-3-yl group).COPYRIGHT: (C)2012,JPO&INPIT【課題】2型糖尿病にも有効な慢性炎症性疾患治療剤を提供する。【解決手段】次式(I):[式中、Ar1及びAr2のいずれか一方は置換基として少なくともニトロ基を有する芳香族基を表し;R1はH原子又はアルキル基を表し;R2はH、アルキル基又は芳香族基、あるいは-CONH-を表し、Ar2の2位に結合し;R1及びR2は共同して次式:-C(R3)(R4)-C(R5)(R6)-で示される基を表してもよい。]で示される化合物又はその塩(但し、Ar1が2-ニトロフェニル基、Ar2が3-シクロペンチルオキシ-4-メトキシフェニル基、R1がH、R2がHである化合物、及びAr1が2,4-ジニトロフェニル基、Ar2が3,4,5-トリメトキシフェニル基、R1がH、R2が6-メトキシ-2-(1-メチル-1H-ピラゾール-4-イル)ベンゾ[b]フラン-3-イル基である化合物を除く。)を含有する慢性炎症性疾患治療剤。【選択図】なし
