Carboxamide derivatives and uses thereof

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专利权人:

パーデュー、ファーマ、リミテッド、パートナーシップ

发明人:

ヤオ，ジャンチャオ,タフェッセ，レイキー,ヤオ,ジャンチャオ,タフェッセ,レイキー

申请号：

JP2016501929

公开号：

JP6186494B2

申请日:

2014.03.13

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: R10 Z-HET-E I-A and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R10 and E are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I-A to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

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