FEDERALNOE GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO OBRAZOVANIJA "MOSKOVSKIJ GOSUDARSTVENNYJ UNIVERSITET IMENI M.V. LOMONOSOVA" (MGU)
发明人:
MOJSENOVICH MIKHAIL MIKHAJLOVICH,Мойсенович Михаил Михайлович,AGAPOV IGOR IVANOVICH,Агапов Игорь Иванович,RAMONOVA ALLA ALIKOVNA,Рамонова Алла Аликовна,ARKHIPOVA ANASTASIJA JUREVNA,Архипова Анастасия
申请号：
RU2013137675
公开号：
RU2563992C2
申请日:
2013.08.12
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to a composite matrix for bone tissue regeneration, a method of obtaining and application thereof. The composite matrix for bone tissue regeneration includes 60% of fibroin, 10% of gelatine and 30% of hydroxyapatite, with the size of matrix pores constituting 150-300 mcm. The method of obtaining the composite matrix consists in mixing hydroxyapatite with NaCl, dissolution of gelatine and fibroin in a solution of lithium chloride in formic acid, centrifugation of the solution, containing fibroin and gelatine, layer-by-layer application of the supernatant in a mould, mixing it with a mixture of hydroxyapatite with NaCl, drying samples, further drying at room temperature, processing the obtained matrix with ethanol alcohol, washing with bidistilled water, degassing under specified conditions. The method of bone tissue regeneration consists in the introduction of an effective amount of the matrix into the region of an injury of the bone tissue of the subject who needs it. Application of the composite matrix for bone tissue regeneration is described.EFFECT: described matrix possesses high strength and good biocompatibility, as well as bioinertness and an ability of biodegradation, which makes it possible to apply them for bone tissue regeneration successively.4 cl, 3 dwg, 2 exГруппа изобретений относится к фармацевтической промышленности, а именно к композитному матриксу для регенерации костной ткани, способу его получения и применения. Композитный матрикс для регенерации костной ткани, включающий 60% фиброина, 10% желатина и 30% гидроксиапатита, при этом размер пор матрикса составляет 150-300 мкм. Способ получения композитного матрикса, заключающийся в смешивании гидроксиапатита с NaCl, растворении желатина и фиброина в растворе лития хлористого в муравьиной кислоте, центрифугировании раствора, содержащего фиброин и желатин, послойном нанесении супернатанта в фо
