Compounds and methods for inhibiting the NHE-mediated antibody in the treatment of disorders associated with fluid retention or salt overload and disorders of the gastrointestinal tract
BELL, Noah,CARRERAS, Christopher,CHARMOT, Dominique,CHEN, Tao,LEADBETTER, Michael,JACOBS, Jeffrey,LEWIS, Jason
申请号：
ES13753340
公开号：
ES2644309T3
申请日:
2013.08.20
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.
