Ruggero De Maria Marchiano,Valeria Coppola,Matilde Todaro,Micol Eleonora Fiori,Enrico Garaci
申请号：
US14365619
公开号：
US20140356459A1
申请日:
2012.12.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to molecular targets and their use to counteract tumors. Naturally occurring microRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The here claimed approach is efficacious also on Cancer Stem Cells.
