SLACK, FRANK J.,JOHNSON, STEVEN M.,GROSSHANS, HELGE
申请号：
CA2583375
公开号：
CA2583375C
申请日:
2005.09.02
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Naturally occurring miRNAs that regulate human oncogenes and methods of usetherof are described. Suitable nucleic acids for use in the methods andcompositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain thebiological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements ofthe miRNA. The compositions containing nucleic acids are administered to apatient in need of treatment or prophylaxis of at least one symptom ormanifestation of cancer. In one embodiment, the compositions are administeredin an effective amount to inhibit gene expression of one or more oncogenes.Methods for treatment or prevention of at least one symptom or manifestationof cancer are also described.
