Methods for treating cancer resistance to ErbB drugs

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专利权人:

DANA-FARBER CANCER INSTITUTE, INC.;BETH ISRAEL DEACONESS MEDICAL CENTER, INC.;THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL

发明人:

JANNE, PASI, A.,CANTLEY, LEWIS, C.,ENGELMAN, JEFFREY

申请号：

DK08742861

公开号：

DK2076289T3

申请日:

2008.04.11

申请国别(地区):

DK

年份:

2015

代理人:

摘要：

Provided herein are methods for treating cancer that is resistant to treatment with an anti- ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene amplification. The methods involve administering to a subject a combination of an anti- ErbB therapeutic and an anti-MET therapeutic. Also provided are methods for reducing ErbB mediated signaling or PI3 kinase mediated signaling in a cancer cell.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/