БЛЕРИ Матьё (FR),ГОТЬЕ Лорен (FR),ПЕРРО Иван (FR),БОННАФУ Сесиль (FR)
申请号：
RU2014131317
公开号：
RU2014131317A
申请日:
2013.02.07
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A monoclonal antibody that binds to a cell surface-bound MICA polypeptide containing the amino acid sequence of SEQ ID NO: 1, to a surface-linked MICA polypeptide containing the amino acid sequence of SEQ ID NO: 2, and to a MICA-linked surface of the MICA polypeptide, containing the amino acid sequence of SEQ ID NO: 4.2. The antibody according to claim 1, characterized in that said antibody is characterized by an EC50, as estimated using flow cytometry of not more than 5 μg / ml, optionally not more than 3 μg / ml, not more than 2 μg / ml, not more than more than 1 μg / ml or not more than 0.5 μg / ml, binding to cells modified to express on their surface a MICA polypeptide containing the amino acid sequence of SEQ ID NO: 1, cells modified to express on their surface a MICA polypeptide containing amino acid sequence of SEQ ID NO: 2, and cells and modified to express on their surface a MICA polypeptide containing the amino acid sequence of SEQ ID NO: 4.3. The antibody of claim 2, wherein said antibody further binds to a MICA polypeptide comprising the amino acid sequence of SEQ ID NO: 3； optionally characterized in that said antibody is characterized by an EC50 of not more than 5 μg / ml, optionally not more than 3 μg / ml, not more than 2 μg / ml, not more than 1 μg / ml or not more than 0.5 μg / ml, binding to cells modified to express the specified MICA polypeptide on their surface. 4. The antibody of claim 3, wherein said antibody further binds to a MICB polypeptide comprising the amino acid sequence of SEQ ID NO: 6； optionally characterized in that said antibody1. Моноклональное антитело, которое связывается со связанным с клеточной поверхностью полипептидом MICA, содержащим последовательность аминокислот SEQ ID NO: 1, со связанным с клеточной поверхностью полипептидом MICA, содержащим последовательность аминокислот SEQ ID NO: 2, и со связанным с клеточной поверхностью полипептидом MICA, содержащим последовательность аминокислот SEQ ID NO: 4.2. Антитело по п.
