ХОЛЬТЦМАН Дэвид (US),КИМ Джунгсу (US),ЦЗЯН Хун (US),ЭЛТОРЕЙ Адам (US)
申请号：
RU2013130002/10
公开号：
RU2013130002A
申请日:
2011.12.02
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. An isolated antibody, wherein the antibody specifically binds to ApoE, and it is produced from a hybridoma selected from the group consisting of HJ6.1 (a patent deposit number ATCC PT-11805), HJ6.2 (a patent deposit number ATCC PT-11806 ), HJ6.3 (a patent deposit number ATCC PT-11807) and HJ6.4 (a patent deposit number ATCC PT-11808) .2. The isolated antibody of claim 1, wherein the antibody comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 14 and SEQ ID NO: 16.3. The isolated antibody of claim 1, wherein the antibody encoded by a nucleotide sequence comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO : 9, SEQ ID NO: 11, SEQ ID NO: 13 and SEQ ID NO: 15.4. The isolated antibody of claim 1, wherein the antibody is selected from the group consisting of a single chain antibody, antibody fragment, chimeric antibody or humanized antitela.5. Isolated antibody, wherein the antibody specifically binds to ApoE and comprises a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 21, 0-2 substitutions aminokislot.6. Isolated antibody, wherein the antibody specifically binds to ApoE and comprises a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 27, 0-2 substitutions aminokislot.7. Isolated antibody, wherein the antibody specifically binds to ApoE DR3 and comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 33, 0-2 substitutions aminokislot.8. Method of treatment of at least one symptom or characteristic associated with Αβ-plaques in an individual comprising administering to the individual an effective amount of at least one anti ApoE.9. The method of claim 8, wherein leche1. Выделенное антитело, где антитело специфически связывается с ApoE, и его получают из гибридомы, выбранной из группы, состоящей из HJ6.1 (патентный номер
