POLYTHERAPIES CIBLANT DES MITOCHONDRIES POUR UNE CANCEROTHERAPIE

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专利权人:

THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

发明人:

ALTIERI, DARIO C.,GHOSH, JAGADISH C.

申请号：

CA2947604

公开号：

CA2947604A1

申请日:

2015.05.01

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Pharmaceutical compositions for the treatment of cancer are provided. In one embodiment the composition comprises Gamitrinib and a P13K inhibitor selected from PX-866, AZD6482, LY294002. BEZ235, GSK458, GDCO941, ZSTK474, BKM120 and GSK2636771B. Methods of treating cancer are also provided. The present invention is based in part on the inventor's discovery that combination therapy that targets mitochondria eliminates tumor adaptation induced by P13K inhibition, and improves clinical outcome in cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/