Systems and methods for detecting changes in a physiological system are provided. A method comprises embedding time series data relating to the physiological system within a reconstructed phase space and partitioning the reconstructed phase space into a plurality of regions. The method further comprises generating a first matrix having a plurality of cells. A value stored in each cell is based on a probability that the system will transition from a first region associated with the cell to a second region associated with the cell and a rate of separation of trajectories of the embedded data within at least one of the first region and the second region. The first matrix is associated with a normal operating condition of the physiological system. The method further comprises comparing the first matrix and a second matrix based on different data to detect an anomalous condition of the physiological system.
