Adrian Hall,Christopher Neil Farthing,Jose Luis Castro Pineiro
申请号：
US14057403
公开号：
US08940734B2
申请日:
2013.10.18
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a fused aminodihydrothiazine derivative of formula (I):whereinX is hydrogen or fluorine；A is CH or N；Y is methyl, ethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, difluoroethyl, methoxy, ethoxy, methoxymethyl or —C≡N；and pharmaceutically acceptable salts thereof；which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
