The present invention is directed to a method of treating a fungal infection with a fusion peptide that includes a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia. The fungal targeting agent can be a pheromone, such as an alpha-mating pheromone. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms. The fusion peptides can be prepared from the nucleic acids, such as when a vector having the nucleic acid is included in a host cell.
