St. Jude Children's Research Hospital, Inc.;Bruce Blazar;Regents of The University of Minnesota;Brent Koehn;Albert-Ludwigs-Universitaet Freiburg;Peter M;The University of North Carolina at Chapel Hill
发明人:
Blazar, Bruce R.,Koehn, Brent H.,Murray, Peter J.,Ting, Jenny P. Y.,Zeiser, Robert,Miller, Jeff S.
申请号：
AU2016303622
公开号：
AU2016303622A8
申请日:
2016.08.05
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft- versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.
