ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.;REGENTS OF THE UNIVERSITY OF MINNESOTA;ALBERT-LUDWIGS UNIVERSITAET FREIBERG;BLAZAR, BRUCE R.;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;KOEHN, BRENT H.
发明人:
MURRAY, PETER J.,TING, JENNY P. Y.,ZEISER, ROBERT,BLAZAR, BRUCE R.,KOEHN, BRENT H.,MILLER, JEFF S.
申请号：
CA2993806
公开号：
CA2993806A1
申请日:
2016.08.05
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft- versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.
