A solution is proposed for analyzing a body-part (150) perfused with a contrast agent, which has been pre-administered as a bolus to circulate through the body-part with a first passage and possibly with at least one second passage during an analysis interval. A corresponding data-processing method (A1-A14) includes the steps of providing (Al1-A3) at least one input signal indicative of a response to an interrogation signal of a corresponding location of the body-part during the analysis interval, and fitting (A4-A11) each input signal over the analysis interval by an instance of a combined bolus function of time, based on a combination of a first simple bolus function of time modeling the first passage of the contrast agent and at least one second simple bolus function of time each one modeling a corresponding second passage of the contrast agent, being defined by the values of a set of first fitting parameters of the first simple bolus function, a set of second fitting parameters of each second simple bolus function and a delay parameter of each second simple bolus function with respect to the first simple bolus function. In the solution according to an embodiment of the invention, the step of fitting each input signal includes estimating (A4-A5) a peak instant of the input signal when the corresponding response reaches an absolute peak, setting (A6) a truncation interval within the analysis interval according to the peak instant, fitting (A7-A8) a truncated signal defined by the input signal over the truncation interval by an instance of a truncated simple bolus function of time, modeling a single passage of the contrast agent during the truncation interval, being defined by the values of a set of truncated fitting parameters, and initializing (A9) the first fitting parameters, the second fitting parameters of each second simple bolus function and the delay parameter of each second simple bolus function according to the values of the truncated fitting parameters.
