Disclosed are (22E)-2-methylene-22-dehydro-1,24,25-trihydroxy-19-nor-vitamin D3 compounds, their biological activities, and various pharmaceutical uses for these compounds. Particularly disclosed are (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 and (22E)-(24S)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3, their biological activities, and various pharmaceutical uses for these compounds.La présente invention concerne des composés de type (22E)-2-méthylène-22-déshydro-1,24,25-trihydroxy-19-nor-vitamine D3, leurs activités biologiques et diverses utilisations pharmaceutiques desdits composés. L'invention concerne, en particulier, la (22E)- (24R)-2-méthylène-22-déshydro-1α,24,25-trihydroxy-19-nor-vitamine D3 et la (22E)-(24S)-2-méthylène-22-déshydro-1α,24,25-trihydroxy-19-nor-vitamine D3, leurs activités biologiques et diverses utilisations pharmaceutiques desdits composés.
