DELUCA, Hector, F.,PLUM, Lori, A.,BARYACKI, Rafal,CLAGETT-DAME, Margaret
申请号：
USUS2013/077486
公开号：
WO2014/116386A1
申请日:
2013.12.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed are (22E)-2-methylene-22-dehydro-1,24,25-trihydroxy-19-nor-vitamin D3 compounds, their biological activities, and various pharmaceutical uses for these compounds. Particularly disclosed are (22E )-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-viiamin D3 and (22E)-(24S)-2-methylene-22-dehydro-1α,24,25-triliydroxy-19-nor-vitamin D3, their biological activities, and various pharmaceutical uses for these compounds.La présente invention concerne des composés de type (22E)-2-méthylène-22-déshydro-1,24,25-trihydroxy-19-nor-vitamine D3, leurs activités biologiques et diverses utilisations pharmaceutiques desdits composés. L'invention concerne, en particulier, la (22E)- (24R)-2-méthylène-22-déshydro-1α,24,25-trihydroxy-19-nor-vitamine D3 et la (22E)-(24S)-2-méthylène-22-déshydro-1α,24,25-trihydroxy-19-nor-vitamine D3, leurs activités biologiques et diverses utilisations pharmaceutiques desdits composés.
