COMPOSE DE N-PHENYLARYLSULFONAMIDE, COMPOSITION PHARMACEUTIQUE COMPRENANT CE COMPOSE EN TANT QUE PRINCIPE ACTIF, INTERMEDOAIRE SYNTHETIQUE POUR CE COMPOSE ET PROCEDE DE PREPARATION
An N-phenylarylsulfonylamide compound of formula (I)(see formula I)(R1 is COOH etc.； R2 is hydrogen, methyl, etc.； R3 and R4 are a combination ofmethyland methyl, etc.； R5 is isopropyl etc, Ar is thiazolyl, pyridyl, 5-methyl-2-furyl eachoptionally substituted with methyl； n is zero or 1), a synthetic intermediatefor thecompound and a process for its preparation. The compound of formula (I) bindsto aprostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizesit. It isless affected by protein binding, so it has a satisfactory in vivo activity.Therefore, it isconsidered to be useful as an analgesic, an antipyretic agent, an agent forthe treatmentof pollakiuria (frequent urination) and/or lower urinary tract diseasesyndrome or anantineoplastic agent.
