Trifluormetil-alkoholok ROR-gamma-t modulátoraiként

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专利权人:

Janssen Pharmaceutica NV

发明人:

VENKATESAN, Hariharan,TANIS, Virginia,KINZEL, Olaf,GEGE, Christian,STEENECK, Christoph,KLEYMANN, Gerald,HOFFMANN, Thomas,GOLDBERG, Steven,FOURIE, Anne,XUE, Xiaohua

申请号：

HUE15802227

公开号：

HUE043624T2

申请日:

2015.10.30

申请国别(地区):

HU

年份:

2019

代理人:

摘要：

The present invention comprises compounds of Formula I. wherein: X, A 1 , A 2 , A 3 , A 4 , R 1 , R 2 , and R 3 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORyt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

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中国工程科技知识中心

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http://www.ckcest.cn/home/