Trifluorometylowane alkohole jako modulatory ROR-gamma-t

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专利权人:

Janssen Pharmaceutica NV

发明人:

VENKATESAN, HARIHARAN,TANIS, VIRGINIA,KINZEL, OLAF,GEGE, CHRISTIAN,STEENECK, CHRISTOPH,KLEYMANN, GERALD,HOFFMANN, THOMAS,GOLDBERG, STEVEN,FOURIE, ANNE M.,XUE, XIAOHUA

申请号：

PL15802227

公开号：

PL3212643T3

申请日:

2015.10.30

申请国别(地区):

PL

年份:

2019

代理人:

摘要：

The present invention comprises compounds of Formula I. wherein: X, A 1 , A 2 , A 3 , A 4 , R 1 , R 2 , and R 3 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORyt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

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