TRIFLUOROMETIL ALKOHOLI KAO MODULATORI ROR-GAMA-T

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专利权人:

Janssen Pharmaceutica NV

发明人:

Venkatesan, Hariharan,Tanis, Virginia,Kinzel, Olaf,Gege, Christian,Steeneck, Christoph,Kleymann, Gerald,Hoffmann, Thomas,Goldberg, Steven,Fourie, Anne M.,Xue, Xiaohua

申请号：

HRP20190900

公开号：

HRP20190900T1

申请日:

2019.05.15

申请国别(地区):

HR

年份:

2019

代理人:

摘要：

The present invention comprises compounds of Formula I. wherein: X, A 1 , A 2 , A 3 , A 4 , R 1 , R 2 , and R 3 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORyt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/