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compound use of a compound and pharmaceutical composition
专利权人:
GLAXO GROUP LIMITED
发明人:
Ann Louise Walker,Christopher Wellaway,Clement Douault,David Matthew Wilson,Hawa Diallo,John Liddle,Matthew Campbell,Michael David Barker,Neil Stuart Garton,Robert John Sheppard,Stephen John Atkinson
申请号：
BR112015001545
公开号：
BR112015001545A2
申请日:
2012.07.26
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
1/1 summary "compounding, use of a compound, and pharmaceutical composition" compounds of formula (i): (i) wherein； r is hydrogen or alkyl c； R is hydrogen, alkyl c, per 1 1-6 2 1-6 halomethylalkyl-, or alkoxy c； R is hydrogen, alkyl c, or alkoxy 0-5 1-6 3 1-6 c alkyl c； R is hydrogen, alkyl c, perhalomethylalkyl c； or 1-6 1-6 4 1-6 1-6 cycloalkyl-unsubstituted alkyl； a is c-r or n； b is c-r or n； d 3 6 1-6 5 6 is c-r or n； with the proviso that at least one of a, b and d is n； R 7 is hydrogen or alkyl c； r is hydrogen or alkyl c； R is hydrogen, 1-6 6 1-6 7 alkyl c, alkoxy c, or hydroxy； R is hydrogen or alkyl c, provided that 1-6 1-6 8 1-6 provided that one of r and r is hydrogen； r is hydrogen or hydroxy； 4 8 9 r is hydrogen or alkyl c； and salts thereof are pad4 inhibitors and may be used in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, lupus cutaneous erythematosus and psoriasis.1 / 1 resumo “composto, uso de um composto, e, composiã‡ãƒo farmacãšuticaâ€� compostos da fã³rmula (i): (i) em que； r ã© hidrogãªnio ou alquila c ； r ã© hidrogãªnio, alquila c , per- 1 1-6 2 1-6 halometilalquilc -o-, ou alcã³xi c ； r ã© hidrogãªnio, alquila c , ou alcã³xi 0-5 1-6 3 1-6 c alquila c ； r ã© hidrogãªnio, alquila c , per-halometilalquila c ； ou 1-6 1-6 4 1-6 1-6 cicloalquilc - alquila c nã£o substituãdo； a ã© c-r ou n； b ã© c-r ou n； d 3 6 1-6 5 6 ã© c-r ou n； com a condiã§ã£o de que pelo menos um de a, b e d seja n； r ã© 7 5 hidrogãªnio ou alquila c ； r ã© hidrogãªnio ou alquila c ； r ã© hidrogãªnio, 1-6 6 1-6 7 alquila c , alcã³xi c , ou hidrã³xi； r ã© hidrogãªnio ou alquila c , com a 1-6 1-6 8 1-6 condiã§ã£o de que um de r e r seja hidrogãªnio； r ã© hidrogãªnio ou hidrã³xi； 4 8 9 r ã© hidrogãªnio ou alquila c ； e seus sais sã£o inibidores de pad4 e podem 10 1-6 ser usados no tratamento de vã¡rios distãºrbios, por exemplo, artrite reumatã³ide, vasculite,
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