Ma, Dangshe,Nagashima, Kirsten,Kennedy, Brian,Donovan, Gerald P.,Kang, Yun,Olson, William C.,Kumar, Shankar,Tsurushita, Naoya,Marozsan, Andre J.,Cupo, Albert
申请号：
AU2011239470
公开号：
AU2011239470B2
申请日:
2011.04.15
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Provided herein are reagents, compositions, and therapies with which to treat Clostridium difficile infection and related disease conditions and pathologies, such as Clostridium difficile-associated diarrhea, resulting from infection by Clostridium difficile bacteria and the enterotoxins produced by these bacteria. In particular, antibodies or antigen- binding fragments thereof that bind specifically to toxin A and/or toxin B of C difficile and neutralize the activities of these toxins； compositions comprising such antibodies； and methods of using the antibodies and the compositions are provided.
