Kirsten Nagashima;Shankar Kumar;Naoya Tsurushita;Yun Kang;William C. Olson;Brian Kennedy;Andre J. Marozsan;Dangshe Ma;Albert Cupo;Gerald P. Donovan
发明人:
Dangshe Ma,Kirsten Nagashima,Brian Kennedy,Gerald P. Donovan,Yun Kang,William C. Olson,Shankar Kumar,Naoya Tsurushita,Andre J. Marozsan,Albert Cupo
申请号：
US13641315
公开号：
US20130202618A1
申请日:
2011.04.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided herein are reagents, compositions, and therapies with which to treat Clostridium difficile infection and related disease conditions and pathologies, such as Clostridium difficile-associated diarrhea, resulting from infection by Clostridium difficile bacteria and the enterotoxins produced by these bacteria. In particular, antibodies or antigen-binding fragments thereof that bind specifically to toxin A and/or toxin B of C difficile and neutralize the activities of these toxins； compositions comprising such antibodies； and methods of using the antibodies and the compositions are provided.
