The present invention provides Factor IX (FIX) fusion proteins comprising at least one heterologous moiety, such as an XTEN. The present invention further discloses methods of making and using the FIX fusion proteins.本發明提供包含至少一個諸如XTEN之異源部分的因子IX(FIX)融合蛋白。本發明另外揭示製備及使用該等FIX融合蛋白之方法。