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Normuramyl glycopeptide compounds
专利权人:
Karsten Hipler
发明人:
Karsten Hipler,Andrew Miller,Jaroslav Turanek,Miroslav Ledvina
申请号:
US12922663
公开号:
US08653049B2
申请日:
2009.03.17
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (II), wherein R1 R4 R5 R6 and R7 are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipid acyl moiety R2 is a hydroxyl, a hydrocarbyl, a lipid moiety, a lipid acyl moiety or an amino hydrocarbyl group optionally substituted with a hydrocarbyl, a lipid moiety or a lipid acyl moiety R3 and R8 are each independently selected from acetyl, a hydrocarbyl, a lipid moiety and a lipid acyl moiety X is a peptide chain The above normuramylglycopeptide compounds can be located in liposomes and micelles and can function as immunomodulators, along with a desired antigen (or DNA encloding the antigen), in (e.g. DNA) vaccines.
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