INDUSTRY-ACADEMIC COOPERATION FOUNDATION; SOOKMYUNG WOMENS UNIVERSITY
发明人:
PARK, Jong Hoon,박종훈,KONG, Hyun Kyung,공현경,KIM, Ye Sol,김예솔,LEE, Yeon Seon,이연선
申请号：
KRKR2016/002215
公开号：
WO2016/140552A1
申请日:
2016.03.04
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The present invention relates to a biomarker composition for diagnosing the sensitivity to an anticancer agent in anticancer agent-resistant breast cancer, a diagnosis kit, a diagnosis method, or a pharmaceutical composition for promoting anticancer effects, wherein it is possible to help effective treatment of tumors by restoring the sensitivity to anticancer agents such as tamoxifen, etc. if the expression of LY6K is inhibited or miR-192-5p is suppressed in breast cancer cells. Also, it is possible to help effective treatment of tumors by restoring the sensitivity to anticancer agents such as tamoxifen, etc. if the expression of miR-500a-3p is induced or miR-500a-3p is applied in breast cancer cells.La présente invention concerne une composition de biomarqueur pour le diagnostic de la sensibilité à un agent anticancéreux dans le cancer du sein résistant à un agent anticancéreux, un kit de diagnostic, un procédé de diagnostic ou une composition pharmaceutique pour favoriser des effets anticancéreux, permettant de soutenir un traitement efficace de tumeurs par le rétablissement de la sensibilité à des agents anticancéreux, tels que le tamoxifène, etc. si lexpression de LY6K est inhibée ou si miR-192-5p est supprimé dans les cellules du cancer du sein. De même, il est possible de soutenir un traitement efficace de tumeurs par le rétablissement de la sensibilité à des agents anticancéreux tels que le tamoxifène, etc. si lexpression de miR-500a-3p est induite ou si miR-500a-3p est administré dans les cellules du cancer du sein.본 발명은 항암제 내성 유방암에 대한 항암제 민감성 진단용 바이오마커 조성물, 진단키트, 진단 방법 또는 항암효과 증진용 약학 조성물에 관한 것으로써, 유방암 세포에서 LY6K의 발현을 억제하거나 miR-192-5p를 저해하면 타목시펜 등 항암제에 대한 민감성을 회복하게 되어 원활한 종양 치료를 도울 수 있다. 또한 유방암 세포에서 miR-500a-3p의 발현을 유도하거나 miR-500a-3p를 가하면 타목시펜 등 항암제에 대한 민감성을 회복하게 되어 원활한 종양 치료를 도울 수 있다.
