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DERIVES D'INDAZOLE ET D'ISOQUINOLEINE EN TANT QU'INHIBITEURS DE ROCK
专利权人:
AMAKEM NV
发明人:
BOURIN, ARNAUD PIERRE JEAN,LEYSEN, DIRK,DEFERT, OLIVIER,BOLAND, SANDRO
申请号:
CA2922312
公开号:
CA2922312A1
申请日:
2013.10.31
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases. Compounds of the invention display soft drug characteristics, i.e. they are rapidly inactivated upon entry in the systemic circulation. Therefore, they allow for reduced systemic exposure to functionally active ROCK inhibitors.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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