SHORT, Jay M.,CHANG, Hwai Wen,FREY, Gerhard,華文昌,FREY, Gerhard,格哈德‧弗雷
申请号：
HK18112826
公开号：
HK1253684A1
申请日:
2018.10.09
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
A non-naturally occurring polypeptide or isolated polypeptide having a ratio of at least 1.3 of an activity in an assay at a first pH in the presence of at least one species having a molecular weight of less than 900 a.m.u. and a pKa up to 4 pH units away from said first pH, to an activity in an assay at a second pH in the presence of the same at least one species. The species has a pKa beween said first pH and said second pH and can be a small molecule. Also disclosed are pharmaceutical formulations including the polypeptide and uses thereof. Methods of producing conditionally active polypeptides are also disclosed.
