UNIT, HYBRIDOMA, PHARMACEUTICAL COMPOSITION, METHOD FOR IDENTIFYING A UNIT, ANTIBODY ISOLATED TO A SAME ANTIGEN CONNECTION UNIT, PEPTIDES MOLECULE, AND UNIT USE.
JOSEPH SCHLESSINGER,IRIT LAX,SATORU YUZAWA,YARDEN TOWSKY,YAN YANG
申请号：
BRPI0812400
公开号：
BRPI0812400A2
申请日:
2008.06.05
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
