GALILI, URI,PICKFORD, CHRISTOPHER,GRIFFITHS, GRAHAM JOHN CHARLES
申请号：
CA2948439
公开号：
CA2948439C
申请日:
2015.05.08
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention relates to pharmaceutical compositions comprising a-Gal BOEL for use in treating patients with tumours. The invention also relates to methods of treating tumours using said compositions. The invention discloses that following intratumoural injection of a- Gal BOEL, binding of the natural anti-Gal antibody to de novo expressed tumoural a-Gal epitopes induces inflammation resulting in an anti-Gal antibody mediated opsonization of tumour cells and their uptake by antigen presenting cells. These antigen presenting cells migrate to draining lymph nodes and activate tumour specific T cells thereby converting the treated tumour lesions into in situ autologous tumour vaccines. This therapy can be applied to patients with multiple lesions and in neo-adjuvant therapy to patients before tumour resection. In addition to the regression and/or destruction of the treated tumour, such a vaccine will help in the immune mediated destruction of micrometastases that are not detectable during the removal of the treated tumour. The invention further teaches the enhancement of anti-tumour a-Gal BOEL treatment by the use of antibodies that inhibit the activity of immunological checkpoints molecules.
