The present invention provides compounds of Formula (I)that act as glucokinase activators pharmaceutical compositions thereof and methods of treating diseases, disorders, or conditions mediated by glucokinase.本發明提供一種作為葡萄糖激酶活化劑之式(I)化合物:其醫藥組合物;及治療由葡萄糖激酶所介導之疾病、失調或病症之方法。