Silke Mark;Monica Alvisi;Maria Angeles Martinez Vargas;Jason Schense
发明人:
Jason Schense,Silke Mark,Monica Alvisi,Maria Angeles Martinez Vargas
申请号：
US13226618
公开号：
US20120234718A1
申请日:
2011.09.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A pharmaceutical formulation for use in a spinal fusion method, comprising a composition for forming a matrix, a kit comprising the composition, a pharmaceutical product obtainable from the pharmaceutical formulation, and an interbody spinal fusion cage containing the pharmaceutical formulation or the pharmaceutical product are described herein. The composition comprises at least a first matrix material precursor component and a second matrix material precursor component that are able to crosslink to form the matrix under appropriate conditions, a bioactive factor that is biologically active for stimulating bone formation between two vertebrae and for effecting or supporting spinal fusion. The bioactive factor is PTH, optionally a PTH fusion peptide. The bioactive factor is releasably incorporated in the matrix upon crosslinking of the matrix material precursor components.
