An imaging guidance planning and treatment system integraged into a single unit or assembly of components and a method for using same. The system utilizes the novel process of Radio Frequency Electrical Membrane Breakdown ( or RFEMB) to destrov the cellular membranes of unwanted or cancerous tissue without denaturing the intra cellular contents of the cells comprising the tissue thereby ablating it and exposing tumor antigens and other intra cellular components which can have an immunologic effect on local or distant cancerous tissue with or without the addition of immunologic adjuvant drugs agents or materials. The system preferably comprises at least one RFEMB treatment probe (20) at least one trackable biopsy needle (200) at least one trackable anesthesia needle (300) and at least one controller unit for at least partially automating the treatment process.
