One embodiment of the present invention consists of a non-rigid,epigenetic-pneumopedic appliance comprising a wire-type frameworksupporting bow, bands, brackets or a clasp. The appliance includes activeelements adapted to provide brief doses of cyclic forces to induce suturalosteogenesis. The active elements are vibrational, ultrasonic or oscillatorycomponents. The epigenetic-pneumopedic appliance cooperates with anactuator or other expansion mechanism, such as suture spring, that straddlesthe midline of the appliance. The appliance further includes tooth-contactingmaterial having high-elasticity, such as pre-formed alloys that form 3-D axialsprings, which adapt to the long axis of the palatal/lingual surfaces of theteeth.The appliance also includes a plurality of micro-screws 2 along with drivingmeans preferably consisting of either an electrical, ultrasonic (vibrational)meso-motor,or, alternatively, a micro-motor. The epigenetic-pneumopedic appliancemay be used with directional bite props.