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PYRROLOBENZODIAZÉPINES ET CONJUGUÉS CIBLÉS
专利权人:
MedImmune Limited;Seattle Genetics, Inc.;SEATTLE GENETICS INC
发明人:
申请号:
EP12840661.8
公开号:
EP2755642B1
申请日:
2012.10.12
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
A Conjugate having formula IV: L - (LU-D) P (IV) or a pharmaceutically acceptable salt or solvate thereof; wherein L is a Ligand Unit selected from the group consisting of an antibody and an antigen-binding fragment of an antibody, LU is a Linker Unit, p is 1 to 20; and D is selected from the group consisting of D1 to D6 having the structures as defined in claim 1 and wherein LU is: wherein the asterisk indicates the point of attachment to D, the wavy line indicates the point of attachment to the Ligand Unit, Y is NH and E is glucuronic acid; and A 1 is a Stretcher Unit.
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