ЗУРАВСКИ Герард (US),БАНШЕРО Жак Ф. (US),ФЛАМАР Анне-Лаур (US)
申请号：
RU2013110889/10
公开号：
RU2013110889A
申请日:
2011.08.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A composition comprising: specific to dendritic (DC) cells, the antibody or binding fragment thereof, conjugated to agonist TLR and at least one antigen, wherein the antigen and the agonist are effective to invoke an immune response in a human or an object-object-animal in need of immunostimulyatsii.2. Composition according to claim. 1, where specific to DC antibody or fragment thereof selected from antibodies to DCIR, MHC class I, MHC class II, CD1, CD2, CD3, CD4, CD8, CD11b, CD14, CD15, CD16, CD19, CD20, CD29 , CD31, CD40, CD43, CD44, CD45, CD54, CD56, CD57, CD58, CD83, CD86, CMRF-44, CMRF-56, DCIR, DC-ASPGR, CLEC-6, CD40, BDCA-2, MARCO, DEC -205, mannose receptor, Langerin, DEKTINU-1, B7-1, B7-2, receptor, IFN-γ and IL-2 receptor, ICAM-1 receptor, Fcγ, LOX-1 or ASPGR.3. Composition according to claim. 1, wherein the composition further comprises an antigenic peptide selected from antigens and gene products of the human immunodeficiency virus (HIV), selected from the group consisting of gag genes, pol and env, Nef protein, reverse transcriptase, a number of HIV peptides (Hipo5) tetramer (KLQCVDLHV) PSA, prepared from gag of HIV p24-PLA p24 gag HIV (gag) and other components of the HIV antigen of hepatitis virus antigens, and influenza virus peptides selected from the group consisting of hemagglutinin, neuraminidase, hemagglutinin HA-1 virus influenza And from a strain of the influenza virus H1N1, the peptide (GILGFVFTL) tet Amer HLA-A201-FluMP (58-66) and antigen of avian influenza virus (HA5-1), dokerinovogo domain C. thermocellum, measles virus antigens, antigens of the rubella virus, rotavirus antigens, cytomegalovirus antigens, antigens of the respiratory syncytial virus antigens herpes simplex virus, varicella zoster virus antigens, Japanese encephalitis virus antigens, antigens rabies virus or a combination thereof and modifikatsiy.4. Composition according to claim. 1, wherein the composition supple
