The present relates to Multifunctional and / or such Antibodies, Antigen binding Fragments that bind to and inhibit the activity of both the Human epidermal growth factor receptor (EGFR) and met (Human receptor for Human hepatocyte growth factor (HGF), and Are effective in the treatment of cancers and other diseases.Disorders or conditions where the pathogenesis is mediated by EGFR and met.Claim 1: a multifunctional Antibody, characterized in that it comprises: (a) an Antibody that binds to met and includes: i) a heavy chain CDR includes heavy chain hcdr1, hcdr2, and hcdr3 consisting of amino acid sequences of gytftdyymh (SEC ID no. 11), rvnpnrrgttynqk FEG (SEC ID no. 12), and aranwldy (SEC ID no. 13)Respectively； and (ii) a light chain comprising the CDRs of light chain lcdr1, lcdr2 and lcdr3 consisting of amino acid sequences of svsssvssiylh (SEC ID no. 14), ystsnlas (SEC ID no. 15) and qvysgyplt (SEC ID no. 16), respectively； and (b) a polypeptide that binds scFv the EGFR And includes: i) a domain that includes hcvr CDRs scFv scFv hcdr1, scFv hcdr2,And hcdr3 scFv which consist of sequences of amino acid； gfsltnygvh (SEC ID no. 1), vix u00b9sggntdyntpfx u00b2g (SEC ID no. 9), which is x u00b9 and or W, X is K or t, and araldyydydfay (SEC ID no. 3), respectively； and (ii) a domain that includes lcvr CDRs scFv scFv lcdr1, scFv lcdr2 scFv, and lcdr3 co Nsisten amino acid sequences rasysigtnih (SEC ID no. 4), x u00b9yax u00b2x u00b3sis (SEC ID no. 10)Where is x u00b9 R and X is K or s, and x's and o r, and qqnnawptt (SEC ID no. 6) respectively.La presente se refiere a anticuerpos multifuncionales, y/o tales fragmentos de unión al antígeno, que se unen a, e inhiben la actividad de, tanto el receptor del factor de crecimiento epidermal humano (EGFR) y MET (receptor humano para el factor de crecimiento del hepatocito humano (HGF)), y que son efectivos en el tratamiento de cánceres y otras enfermedades, trastornos o condiciones donde la patogénesis es mediada por EGFR y
