Loading drug in plate-shaped device, by inverse electrophoresis, for transdermal administration of drug by iontophoresis, comprises loading drug in polymer plate, where loading step includes withdrawing drug loaded plate and then drying
Process comprises loading an ionized amphiphilic drug solution (25) in a flexible polymer plate (10) having an electric conductivity, where the loading step is carried out by: placing the plate in a reservoir (21) and then connecting to an electric generator, closing a lid of a loading cell, feeding the cell with the solution, connecting an electrode to the generator, determining electric parameters of the plate, adjusting an electric circuit when a quantity of the solution is 1-30 wt.%, withdrawing the plate loaded with drug solution and then drying and hermitically packing the loaded plate. Process comprises loading an ionized amphiphilic drug solution (25) in a flexible polymer plate (10) having an electric conductivity, where the loading step is carried out by: placing the plate on supports (24) in a reservoir (21) and then connecting to an electric generator at an end, closing a lid of a loading cell including the reservoir, feeding the cell with the drug solution through a feed neck (23), connecting an electrode to the generator, determining electric parameters such as voltage, current intensity and duration of electric impulse of the plate, activating the generator, adjusting an electric circuit when a quantity of the drug solution is 1-30 wt.%, emptying the cell, opening the lid, withdrawing the plate loaded with the drug solution, drying the loaded plate, and hermitically packing the loaded plate under vacuum or in an inert atmosphere. An independent claim is included for a plate-shaped device for the transdermal administration of drug by iontophoresis, comprising flexible conductive polymer matrix (70-99 wt.%) and ionized amphiphilic drug solution (1-30 wt.%).L'invention concerne un procédé de chargement par électrophorèse inverse d'une solution médicamenteuse ionisée amphiphile dans une plaquette polymère flexible conductrice (10) permettant l'administration transdermique iontophorétique de ladite solution médicamenteuse. Le chargement de ladite plaquette
